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. 2014 Feb;82(2):773–782. doi: 10.1128/IAI.00971-13

TABLE 1.

Bphs, Bpss, and Bpbs of inbred micea

Strain Bphs
 Bpss
 LD50 Bpbs
 LD50
Carrier + 5-HT (50 mg/kg) PTX + 5-HT at:
 Carrier + Bdk (80 mg/kg) PTX + Bdk at:
Carrier + HA (25 mg/kg) PTX + HA (25 mg/kg) 50 mg/kg 12.5 mg/kg 3.1 mg/kg 0.78 mg/kg 0.39 mg/kg 80 mg/kg 40 mg/kg 20 mg/kg 10 mg/kg
SM/J 0/4 4/4b 0/4 4/4b 5/5 5/6 3/6 0/4 1.0 0/4 4/4b 2/4 0/4 0/4 40.0
SJL/J 0/4 4/4b 0/4 12/12c 12/12 6/11 0/8 2.6 0/4 4/4b 4/4 1/4 0/4 22.5
AKR/J 0/4 0/4 0/4 12/12c 10/10 8/17 0/8 3.2 0/4 4/4b 3/4 0/4 0/4 35.6
MRL/MpJ 0/4 0/4 0/4 4/4b 6/6 4/8 0/4 2.9 0/4 2/4 1/4 0/4 0/4
LG/J 0/4 4/4b 0/4 4/4b 7/8 0/4 5.4 0/4 2/4 0/4 0/4 0/4
RFM/UnNCr 0/4 4/4b 0/4 6/6d 0/6 0/4 26.2
PL/J 0/4 4/4b 0/4 6/6d 0/8 0/4 29.8
DBA/1J 0/4 4/4b 0/4 5/5d 0/6 0/4 28.6
SWR/J 0/4 4/4b 0/4 6/6d 0/4 0/4 22.0
C57BL/6J 0/4 4/4b 0/4 9/15 0/14 0/8 0/4 4/4b 4/4 0/4 0/4 28.3
DBA/2J 0/4 4/4b 0/4 4/15 0/14 0/4 0/4 4/4b 2/4 0/4 0/4 40.0
A/J 0/4 4/4b 0/4 2/15 0/12 0/4 0/4 4/4b 2/4 0/4 0/4 40.0
A/HeJ 0/4 4/4b 0/4 3/6 0/6 0/4 0/4 4/4b 4/4 2/4 0/4 20.0
NOD/LtJ 0/4 4/4b 0/4 2/6 0/8 0/4
FVB/NCr 0/4 4/4b 0/4 2/6 0/8 0/4
C57BL/10J 0/4 4/4b 0/4 1/6 0/4 0/4 0/4 2/4 0/4 0/4 0/4
NZB/BlnJ 0/4 4/4b 0/4 3/8 0/6 0/4 0/4 4/4b 3/4 2/4 0/4 22.1
NZW/LacJ 0/4 4/4b 0/4 2/9 0/6 0/4 0/4 4/4b 4/4 2/4 0/4 20.0
129X1/SvJ 0/4 4/4b 0/4 6/10 5/14 1/5 0/4 0/4 4/4b 3/4 2/4 0/4 22.1
BALB/cJ 0/4 4/4b 1/4 3/10 6/17 0/5 0/4 0/4 4/4b 4/4 2/4 0/4 20.0
BALB/cByJ 0/4 4/4b 0/4 0/9 0/6 0/4 0/4 4/4b 2/4 0/4 0/4 40.0
CBA/JCr 0/4 0/4 0/4 0/8 0/8 0/4
B10.D2n 0/4 4/4b 0/4 0/9 0/6 0/4 0/4 2/4 0/4 0/4 0/4
B10.S/SgSnJ 0/4 4/4b 0/4 1/10 0/6 0/4 0/4 1/4 0/5 0/5 0/5
C3H/HeJ 0/4 0/4 0/4 4/14 4/15 0/4 0/4 4/4b 4/4 1/4 0/4 22.5
C3H/HeN 0/4 0/4 0/4 0/4 0/4 0/4 0/4 4/4b 4/4 2/4 0/4 20.0
C3H.BphsSJL 0/4 4/4b 0/4 0/4 0/4 0/4 0/4 4/4b 4/4 2/4 0/4 20.0
a

Animals were sensitized with 200 ng PTX by i.v. injection and challenged 3 days later by i.v. injection of HA (25 mg/kg), 5-HT (0.39 to 50 mg/kg), or BDK (10 to 80 mg/kg). Three or four mice were examined at a given dose. Dosages are based on mg/kg (dry weight) free base or peptide. Deaths were recorded at 30 min, and the results are expressed as the number dead/number studied. LD50s of 5-HT and HA were calculated with GraphPad Prism. Contrasts for combined phenotypes: SM = SJL = AKR = MRL; SM < LG = SJL = AKR = MRL; LG < RFM = PL = DBA/1 = SWR. The significance of differences between carrier- and PTX-treated groups was determined by Fisher's exact test. The significance of differences in LD50s among and between the strains was determined by the extra sum of squares F test. Bpss overall F = 15.9, P < 0.0001; Bpbs overall F = 1.3, P = 0.2.

b

P = 0.05.

c

P < 0.0001.

d

P < 0.01.