TABLE 2.

Inheritance of Bphs, Bpss, and Bpbs in F₁ hybrid strains^a

Phenotype and strain	Classification	No. of mice with phenotype/total (P value)			Contrasts
		Group 1	Group 2	Group 3
Bphs
SJL/J	Bphs+ Bpss+ Bpbs+	6/6b	6/6c	5/6d
C3H/HeJ	Bphs−	0/6b	0/6c	0/6d
(C3H × SJL)F1		6/6b (0.0001)	6/6c (0.0001)	4/6d (0.0094)	SJL/J = (C3H × SJL)F1 > C3H/HeJ
C57BL/6J	Bphs+ Bpbs+	6/6b	6/6c	1/6d
CBA/J	Bphs−	0/6b	0/6c	0/6d
(B6 × CBA)F1		6/6b (0.0001)	6/6c (0.0001)	2/6d (0.3)	C57BL/6J = (B6 × CBA)F1 > CBA/J
Bpss
SJL/J	Bphs+ Bpss+ Bpbs+	12/12e	12/12f	6/11g
PL/J (control)	Bpss+	6/6e	0/8f	0/4g
(PL × SJL)F1		8/9e (0.35)	1/9f (<0.0001)	0/5g (0.03)	SJL/J > PL/J = (PL × SJL)F1
SJL/J		12/12e	12/12f	6/11g
BALB/cJ	Bpss−	3/10e	6/17f	0/5g
(BALB × SJL)F1		6/9e (0.001)	4/8f (0.002)	0/5g (0.02)	SJL/J > BALB/cJ = (BALB × SJL)F1
AKR/J	Bphs+ Bpss+ Bpbs+	12/12e	10/10f	8/17g
DBA/2J	Bpss−	4/15e	0/14f	0/4g
(AK × DBA)F1		4/8e (0.0003)	0/8f (<0.0001)	0/5g (0.05)	AKR/J > DBA/2J = (AK × DBA)F1
SJL		10/10e	10/10f	6/10g
B10.S	Bpss−	1/10e	1/10f	0/10g
(B10 × SJL)F1		1/10e (<0.0001)	0/10f (<0.0001)	0/10g (0.0006)	SJL/J > B10.S = (B10 × SJL)F1
Bpbs
SJL/J	Bphs+ Bpss+ Bpbs+	6/6h	6/6i	4/6j
B10.S	Bpbs−	1/6h	0/6i	0/6j
(B10 × SJL)F1		2/6h (0.009)	1/6i (0.0007)	0/5j (0.008)	SJL/J > B10.S = (B10 × SJL)F1

^aF₁ hybrids were generated by using the indicated parental strains. Mice were then challenged for Bphs, Bpss, or Bpbs at the indicated doses. Significance of difference in susceptibility between parental strains and F₁ hybrids was determined using Fisher's exact test.

^bHA challenge dose, 25 mg/kg free base.

^cHA challenge dose, 12.5 mg/kg free base.

^dHA challenge dose, 3.1 mg/kg free base.

^e5-HT challenge dose, 50 mg/kg free base.

^f5-HT challenge dose, 12.5 mg/kg free base.

^g5-HT challenge dose, 3.1 mg/kg free base.

^hBDK challenge dose, 80 mg/kg peptide.

ⁱBDK challenge dose, 40 mg/kg peptide.

^jBDK challenge dose, 20 mg/kg peptide.