TABLE 4.

Bpss and Bpbs are not linked to 5-HT and BDK receptors, respectively^a

Receptor	Chrb	Distance (cMc)	Size (Mbp)	Marker	Distance (cM)	Size (Mbp)	No. of mice						χ2 value	P value
							Affected			Unaffected
							S	H	B	S	H	B
Bpss
Htr2b	1	52	88	D1Mit10	56.6	93	3	12	2	22	14	39	4.8	0.4
Htr5b		63	123
Htr6	4	65	139	D4Mit203	60	129	2	12	6	25	34	17	4.9	0.4
Htr1d		66	136
Htr5a	5	15	28	D5Mit148	18	32	6	9	3	16	46	14	4.5	0.5
Htr3a	9	29	49	D9Mit105	35	63	9	6	3	21	34	19	6.6	0.3
Htr3b		29	49
Htr1b		46	82
Htr1a	13	58	106	D13Mit75	59	107	3	11	6	20	37	18	1.2	0.9
Htr2a	14	42	75	D14Mit71	44	97	6	11	3	17	36	23	2.3	0.8
Htr1f	16	39	65	D16Mit14	34	51	4	9	7	19	32	25	3.9	0.6
Htr4	18	37	62	D18Mit81	41	67	4	11	5	19	39	18	0.4	1
Htr7	19	33	36	D19Mit88	34	37	6	8	6	20	34	22	1.8	0.9
Htr2c	X	66	143	DXMit36	63	143	2/4d	5	3/6d	5/22d	16	12/27d	3.2/0.1d	0.7/0.8d
Bpbs, Bdkrb1/2	12	52	107	D12Mit7	50	104	7	11	10	14	36	15	3.4	0.6

^a(B10.S × SJL/J) × B10.S N2 backcross mice were phenotyped for Bpss or Bpbs as described for Table 3 (25 mg/kg 5-HT and 40 mg/kg BDK, respectively). B, B10.S; H, heterozygous; S, SJL/J (at indicated position with chromosome location for the gene and closest marker indicated). Genotype frequency differences among affected and unaffected BC1 mice were evaluated by chi-square analysis in two-by-two contingency tables. Significance was tested by Fisher's exact test.

^bChr, chromosome.

^ccM, centimorgans.

^dFemale/male values.