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Bphs is not mediated by eNOSa
| Strain | No. of mice dead/total after challenge with HA at: |
||
|---|---|---|---|
| 50 mg/kg | 12.5 mg/kg | 3.13 mg/kg | |
| C57BL/6J | 4/4 | 4/4 | 2/4 |
| B6.129.P2-Nos3t,m,i/Unc/J | 4/4 | 4/4 | 1/4 |
WT and Nos3-deficient mice were analyzed for Bphs 3 days after the i.v. injection of 200 ng PTX. HA dosages are based on mg/kg (dry weight) free base. Deaths were recorded at 30 min, and the results expressed as the number dead/number studied.
