FIG 3.

Changes in levels of the inflammatory cytokines TNF-α (A) and MIP-2 (B) (36 h after inoculation) in bronchoalveolar lavage fluid from Streptococcus pneumoniae (Sp)-infected mice with or without supernatant of Prevotella intermedia (PiSup) (n = 8 for each group) and from PiSup-inoculated mice (n = 7). All groups contained equal amounts of modified GAM broth and normal saline. TNF-α and MIP-2 levels were significantly higher in S. pneumoniae-infected mice with PiSup than in other groups. TNF-α levels also increased slightly in the PiSup-inoculated group. The data are expressed as means with SEM. Statistically significant differences are indicated as follows: **, P < 0.001.