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Assessment of efficacies of MALDI-TOF MS, MSSCP, INNOLiPA HBV DR, and direct sequencing assays in detection of the HBV polymorphism YMDD motif
| YMDD motif (amino acid)a | No. of motifs with the indicated method of YMDD polymorphism detection (n = 82) |
|||
|---|---|---|---|---|
| MALDI-TOF MS | MSSCP | INNOLiPA HBV DR | Direct sequencing | |
| M | 40 | 40 | 65 | 77 |
| V | 14 | 14 | 8 | 3 |
| I | 10 | 10 | 4 | 2 |
| M/V | 12 | 12 | 3 | 0 |
| M/I | 2 | 2 | 1 | 0 |
| I/V | 3 | 4 | 1 | 0 |
| M/I/V | 1 | 0 | 0 | 0 |
HBV wild type, amino acid M.
