TABLE 1.
Genes differentially expressed upon BYM338 treatment
| Probe set identifier | Gene symbol | Gene name | Fold changea | Adjusted P value |
|---|---|---|---|---|
| 1423261_at | 1500015O10Rik | RIKEN cDNA 1500015O10 gene | 2.31 | 2.39E−03 |
| 1435605_at | Actr3b | ARP3 actin-related protein 3 homolog B (Saccharomyces cerevisiae) | 2.3 | 2.38E−10 |
| 1416835_s_at | Amd1 | S-Adenosylmethionine decarboxylase 1 | 1.91 | 1.45E−06 |
| 1452106_at | Npnt | Nephronectin | 1.86 | 1.39E−05 |
| 1420569_at | Chad | Chondroadherin | 1.82 | 5.51E−03 |
| 1449824_at | Prg4 | Proteoglycan 4 (megakaryocyte-stimulating factor, articular superficial zone protein) | 1.7 | 2.38E−04 |
| 1424268_at | Smox | Spermine oxidase | 1.66 | 2.33E−04 |
| 1460555_at | Fam65b | Family with sequence similarity 65, member B | 1.54 | 5.13E−07 |
| 1427884_at | Col3a1 | Collagen, type III, alpha 1 | 1.48 | 6.43E−08 |
| 1421186_at | Ccr2 | Chemokine (C-C motif) receptor 2 | 1.48 | 1.48E−03 |
| 1423669_at | Col1a1 | Collagen, type I, alpha 1 | 1.46 | 5.75E−10 |
| 1423110_at | Col1a2 | Collagen, type I, alpha 2 | 1.46 | 1.90E−08 |
| 1448424_at | Frzb | Frizzled-related protein | 1.45 | 8.60E−03 |
| 1438009_at | Hist1h2ae | Histone cluster 1, H2ae | 1.43 | 1.08E−04 |
| 1423329_at | Gdap1 | Ganglioside-induced differentiation-associated protein 1 | 1.35 | 3.06E−04 |
| 1422789_at | Aldh1a2 | Aldehyde dehydrogenase family 1, subfamily A2 | 1.31 | 5.12E−04 |
| 1433893_s_at | Spag5 | Sperm-associated antigen 5 | 1.29 | 2.42E−04 |
| 1422847_a_at | Prkcd | Protein kinase C, delta | 1.29 | 4.22E−10 |
| 1418713_at | Pcbd1 | Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1 (TCF1) | 1.25 | 1.90E−08 |
| 1416342_at | Tnc | Tenascin C | 1.25 | 7.89E−03 |
| 1427239_at | Ift122 | Intraflagellar transport 122 homolog (Chlamydomonas) | 1.24 | 1.00E−05 |
| 1425039_at | Itgbl1 | Integrin, beta-like 1 | 1.24 | 6.11E−04 |
| 1416318_at | Serpinb1a | Serine (or cysteine) peptidase inhibitor, clade B, member 1a | 1.22 | 3.38E−03 |
| 1439827_at | Adamts12 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 | 1.22 | 7.55E−07 |
| 1451410_a_at | Crip3 | Cysteine-rich protein 3 | 1.19 | 1.18E−04 |
| 1416601_a_at | Rcan1 | Regulator of calcineurin 1 | 1.15 | 4.83E−06 |
| 1448328_at | Sh3bp2 | SH3 domain binding protein 2 | 1.14 | 1.90E−08 |
| 1459913_at | Tnfsf10 | Tumor necrosis factor (ligand) superfamily, member 10 | 1.14 | 7.85E−04 |
| 1434479_at | Col5a1 | Collagen, type V, alpha 1 | 1.13 | 3.55E−10 |
| 1419703_at | Col5a3 | Collagen, type V, alpha 3 | 1.12 | 7.53E−05 |
| 1434411_at | Col12a1 | Collagen, type XII, alpha 1 | 1.11 | 8.54E−03 |
| 1451105_at | Vash2 | Vasohibin 2 | 1.1 | 1.33E−04 |
| 1442019_at | Rcvrn | Recoverin | 1.1 | 1.45E−03 |
| 1428420_a_at | 1200009I06Rik | RIKEN cDNA 1200009I06 gene | 1.07 | 5.20E−04 |
| 1434997_at | Cdk19 | Cyclin-dependent kinase 19 | 1.05 | 2.13E−10 |
| 1451353_at | Tm6sf1 | Transmembrane 6 superfamily member 1 | 1.05 | 1.47E−05 |
| 1460248_at | Cpxm2 | Carboxypeptidase X2 (M14 family) | 1.04 | 2.82E−03 |
| 1429566_a_at | Hipk2 | Homeodomain-interacting protein kinase 2 | 1.03 | 2.11E−08 |
| 1421926_at | Mapk11 | Mitogen-activated protein kinase 11 | 1.03 | 7.47E−05 |
| 1425156_at | Gbp7 | Guanylate binding protein 7 | 1.02 | 5.30E−03 |
| 1429553_at | Cilp2 | Cartilage intermediate layer protein 2 | 1.01 | 8.92E−03 |
| 1448698_at | Ccnd1 | Cyclin D1 | 1.01 | 3.81E−03 |
| 1421851_at | Mtap1b | Microtubule-associated protein 1B | 1 | 1.13E−02 |
| 1425631_at | Ppp1r3c | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | 1 | 8.77E−03 |
| 1424870_at | Osbpl10 | Oxysterol binding protein-like 10 | 0.98 | 7.72E−07 |
| 1419519_at | Igf1 | Insulin-like growth factor 1 | 0.98 | 1.96E−07 |
| 1460218_at | Cd52 | CD52 antigen | 0.98 | 9.29E−03 |
| 1444128_at | Arhgap26 | Rho GTPase-activating protein 26 | −1.09 | 1.06E−04 |
| 1434628_a_at | C230052I12Rik | RIKEN cDNA C230052I12 gene | −1.12 | 5.02E−09 |
| 1417155_at | Mycn | v-myc myelocytomatosis virus-related oncogene, neuroblastoma derived (avian) | −1.25 | 1.66E−03 |
| 1454995_at | Ddah1 | Dimethylarginine dimethylaminohydrolase 1 | −1.37 | 7.72E−07 |
| 1422580_at | Myl4 | Myosin, light polypeptide 4 | −1.4 | 1.72E−06 |
| 1416383_a_at | Pcx | Pyruvate carboxylase | −1.41 | 2.62E−06 |
| 1428352_at | Arrdc2 | Arrestin domain containing 2 | −1.44 | 2.43E−03 |
| 1445186_at | Stc2 | Stanniocalcin 2 | −1.49 | 2.67E−05 |
| 1418697_at | Inmt | Indolethylamine N-methyltransferase | −1.64 | 1.95E−04 |
| 1447016_at | Tbc1d1 | TBC1 domain family, member 1 | −2.36 | 1.88E−06 |
| 1432001_at | Zmynd17 | Zinc finger, MYND domain containing 17 | −2.61 | 3.92E−04 |
a
Fold changes are expressed in log2 scale.