FIG 3.

CS improved insulin sensitivity in mice with diet-induced or genetic obesity. (A to D) Either C57BL/6J mice fed a high-fat diet for 12 weeks to induce diet-induced obesity (DIO) or 12-week-old ob/ob mice maintained on a chow diet were used. The mice were then treated with a vehicle (VEH) or CS for 2 weeks before analysis. Shown are blood glucose levels (A), results of glucose tolerance tests (GTT) (B) and insulin tolerance tests (ITT) (C), and hepatic gene expression (D) in DIO (left) and ob/ob (right) mice. The percentages in panel C are relative variations from the time 0 min, which was arbitrarily set as 100%. Results are means ± SD; n, 4 mice per group. *, P < 0.05.