FIG 4.

Cytokine and chemokine secretion in dengue virus-infected mice. The tested panel of cytokines and chemokines included some that were detected in plasma of infected humanized mice at days 1 and 3 postinfection. Plots represent the individual mice in each group (ranging from 3 to 8 mice per group at each time point). Results are expressed in picograms per ml. *, statistically significant difference (P < 0.05) between the indicated experimental groups. (B) Spearman correlation coefficients (r) between viral titers and cytokine secretion levels in infected animals. IFN-α2, IL-10, and IP-10 were the only cytokines that showed statistically significant correlations between the viral titer and circulating cytokine level.