FIG 8.
Protection against lethal challenge with MVEV. B6 donor mice (10 mice/group) were immunized (i.m.) with two doses of 105 PFU of either MVEV.C-IRES or MVEV.IFN-β, delivered 3 weeks apart (Table 3), and B cells were isolated at 9 weeks after completion of the vaccination schedule and adoptively transferred into 4-week-old recipients (n = 10/group). Additionally, B cells from naive mice were transferred into control mice (n = 10). One day after the transfer, mice were challenged with 105 PFU of MVEV.wt by footpad injection and monitored twice daily for morbidity and mortality for 28 days.