TABLE 1.
Neuroinvasiveness and neurovirulence in weanling BALB/c micea
| Virus | Route of infection | Dose (PFU) | Mortality (%) | Avg survival time (days) ± SD |
|---|---|---|---|---|
| MVEV.wt | i.p. | 1,000 | 17/17 (100) | 7.9 ± 1.4 |
| 100 | 4/5 (80) | 10.0 | ||
| 10 | 2/5 (40) | 8.0 | ||
| MVEV.C-IRES | 100,000 | 4/10 (40) | 9.0 | |
| 10,000 | 0/5 (0) | |||
| 1,000 | 0/5 (0) | |||
| MVEV.IFN-β | 100,000 | 0/10 (0) | ||
| 10,000 | 0/5 (0) | |||
| 1,000 | 0/5 (0) | |||
| MVEV.C-IRES | i.c. | 10,000 | 3/14 (21) | 8.3 ± 0.6 |
| 1,000 | 0/5 (0) | |||
| MVEV.IFN-β | 10,000 | 1/14 (7) | 9.0 | |
| 1,000 | 0/5 (0) |
a
Groups of 23- to 27-day-old male or female BALB/c mice were infected i.p. or i.c. with the given virus doses, and morbidity and mortality were monitored over a period of 14 days. The data were compiled from 5 experiments.