FIG 5.

CD4 T cells are required for efficacy of NK cell depletion therapy. C57BL/6 mice were either depleted of CD4 T cells (n = 10/group) or treated with isotype control antibody (n = 5/group) at days −1 and +1 of high-dose LCMV clone 13 infection. At days 26 to 29 of infection, groups of mice were either treated with isotype control antibody or depleted of NK cells. LCMV-specific CD8 T cell responses (A) and viral titers (B) were measured in the spleen. These results were pooled from two independent experiments.