FIG 1.

Inhibition of HIV/HA(H5) by MBX2329 and MBX2546. (A) Structures of MBX2329 and MBX2546. Chemical structures and molecular weights (MW) (in thousands) of MBX2329 and MBX2546 are shown. MBX2329 and MBX2546, with aminoalkyl phenol ether and aminoacetamide sulfonamide scaffolds, respectively, were prioritized based on potency and selectivity against HIV/HA(H5). (B and C) The inhibitory effect of compounds MBX2329 (B) and MBX2546 (C) on HIV/HA(H5) infectivity was investigated by using A549 cells as described in Materials and Methods. Three independent experiments were performed to determine the effect of the compounds.