FIG 3.

LANAC protection against intranasal or subcutaneous challenge with WEEV. (A) Mice (n = 10/group) were prime-boost immunized with E1ecto LANACs (LANAC) or sham LANACs (SHAM) and challenged with 10⁴ PFU of WEEV McMillan 2 weeks after the booster. The differences in survival among mice immunized with E1ecto or sham LANACs were statistically significant (P < 0.0001 for s.c. route; P = 0.0359 for i.n. route). (B) Same as panel A except the mice were challenged 11 weeks after the booster dose. Again, the differences in survival among mice immunized with E1ecto or sham LANACs were statistically significant (P < 0.001).