FIG 9.

LANAC cross-protection against EEEV. (A) CD-1 mice were immunized with E1ecto LANACs (LANAC) or sham LANACs (SHAM) and then challenged 9 weeks after the booster with 10⁴ PFU of EEEV (Florida-93) by either the s.c. or i.n. route. The survival curve for each treatment was analyzed and found to be significantly different from that for the sham-immunized control (P < 0.0001 for both s.c. and i.n. routes). (B) CD-1 mice were immunized with E1ecto LANACs (LANAC) or sham LANACs (SHAM) and then challenged 2 weeks after the booster with 10⁴ PFU of EEEV (Florida-93) by either the s.c. or i.n. route. There was no significant difference between the E1ecto LANACs (LANAC) and sham LANAC immunization groups.