FIG 2.

Joint inflammation in DBA/1 mice immunized with mimivirus proteins. (A) Clinical severity of arthritic limbs in the groups of mice immunized with PBS (●), bovine collagen type II (■), recombinant L71 protein (▼), marseillevirus proteins (◆), and mimivirus proteins (▲) are shown as means ± standard errors of the means. The arrow shows the time point of booster immunization. Data represent three independent experiments with 10 to 21 mice per group. (B) Representative H&E-stained sections of hind limbs by day 75 after immunization showing cartilage damage and synovial hyperplasia in mice immunized with bovine collagen type II (BovCII) and mimivirus protein (MV). No signs of pathology were visible in PBS-immunized negative-control mice (Neg). Scale bar, 100 μm.