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A3 inhibits human DHODH in vitro. (A) DHODH catalyzes the conversion of l-dihydroorotic acid to the oxidized orotate, thereby reducing dichloroindophenol (DCIP, blue) into DCIPH2 (colorless). (B) In vitro DHODH inhibition was measured by adding serial dilutions of A3 and the known DHODH inhibitors brequinar, teriflunomide, and leflunomide. DMSO was included as a negative control. IC50s were calculated based on four independent experiments.
