TABLE 2.
The most conserved proteins encoded by 26 HSV-1 genomes
| Protein (locus) | % Identityc | Function |
|---|---|---|
| VP26 (UL35)a | 99.1 | Small capsid protein |
| UL15a,b | 98.8 | DNA packaging terminase subunit 1 |
| UL29a,b | 98.7 | Single-stranded DNA-binding protein |
| UL20 | 98.6 | Envelope protein of unknown function |
| UL28a,b | 98.5 | DNA packaging terminase subunit 2 |
| UL33a,b | 98.5 | DNA packaging protein, interacts with UL28 |
| VP13-14 (UL47) | 98.4 | Tegument protein, modulates transactivating protein VP16 (UL48) |
| UL45 | 98.3 | Membrane protein of unknown function |
| gK (UL53) | 98.2 | Envelope glycoprotein involved in entry |
| VP5 (UL19)a,b | 97.9 | Major capsid protein, forms hexons and pentons |
| RR2 (UL40)a | 97.9 | Ribonucleotide reductase subunit 2 |
| Pol (UL30)a,b | 97.9 | DNA polymerase catalytic subunit |
| UL18a,b | 97.8 | Capsid triplex subunit 2, with capsid triplex subunit 1 (UL38), connects capsid hexons/pentons |
| UL25a,b | 97.8 | DNA packaging tegument protein, stabilizes capsid vertices |
| UL31a,b | 97.7 | Nuclear egress lamina protein |
a
Protein is conserved across the family Herpesviridae.
b
Protein is essential for growth in culture, as described by McGeoch et al. (137).
c
Percentage of amino acid alignment columns that are identical (without mutations). See Materials and Methods for details; see also Table S3 in the supplemental material.