FIG 5.

Viral diversity is higher in progressors than in VC. (A) Pairwise distance is correlated with viral load in this cohort. VC, open circles; progressors, gray squares. (B) From plasma viral RNA populations isolated from progressors and VCs, pairwise distances between Gag sequences corresponding to targeted epitopic regions were calculated and compared between groups (***, P = 0.0005). (C) Proportions of targeted epitopic regions for which recognized variants were present in the viral population (white), variants present in the viral population that were rare and not represented in the peptide set (gray), and variants present in the viral population that were tested but not recognized (black).