FIG 1.
Immunoprevalence of HLA-Cw0801-restricted Env171–180-specific T cell response in Southeast Asian subjects who resolved HBV infection. (A) Bars show the prevalence of the HLA-Cw0801/Env171–180 T cell response in Southeast Asian subjects who resolved HBV infection in comparison to previously characterized HBV epitopes restricted by HLA alleles commonly found in the Southeast Asian population. The inset shows the HLA-Cw0801/Env171–180 T cell response from a representative subject. Cells were gated for CD3 positivity, and the epitope-specific CD8 T cell response is shown as the frequency in the total T cell population. The number of subjects tested and the HLA restriction for each epitope are indicated below the bars. (B) Phenotypic frequency and the geographical distribution of HLA alleles commonly found in the Southeast Asian population. Heat maps and data were obtained from NCBI MHC database (dbMHC [http://www.ncbi.nlm.nih.gov/gv/mhc]).