TABLE 3.
Pathogenicity of avian H2N2 influenza viruses in DBA/2J mice
| Categorya | Animal origin | Virus | Maximum wt lossb | % mortality | Lung titerc | Serologyd | Virulencee |
|---|---|---|---|---|---|---|---|
| Eurasian | Wild | Mal/MT/61 | 11.5 ± 3.7 | 0 | 6.5 ± 0.3 | (3/3) | High |
| Wild | Mal/Pot177/83f | 16.0 ± 4.6 | 0 | 5.6 ± 1.0 | (3/3) | High | |
| Wild | Mal/Pot179/83 | 25.0 ± 4.1 | 60 | 5.8 ± 0.4 | (2/2) | High | |
| Domestic | Dk/HK273/78 | 14.0 ± 3.5 | 20 | 5.4 ± 1.3 | (3/3) | High | |
| Domestic | Dk/HK319/79 | 12.0 ± 7.9 | 100 | 6.9 ± 0.9 | < | High | |
| Domestic | Ck/Jena/83 | 3.0 ± 2.4 | 0 | 5.3 ± 1.4 | (3/3) | Low | |
| Domestic | Ck/Jena/84 | 11.0 ± 5.2 | 0 | 5.3 ± 0.7 | (3/3) | High | |
| North American | Wild | Bwt/Alb/78 | < | 0 | 3.8 ± 0.4 | (3/3) | Low |
| Wild | Mal/NY/78 | 4.0 ± 5.4 | 0 | 5.3 ± 1.1 | (3/3) | Low | |
| Wild | Mal/MN/98 | 4.0 ± 2.3 | 0 | 6.0 ± 0.5 | (3/3) | Low | |
| Wild | Mal/MN/00 | < | 0 | 4.3 ± 0.4 | (3/3) | Low | |
| Wild | Mal/MN/08 | 28.0 ± 4.2 | 80 | 5.3 ± 0.4 | (3/3) | High | |
| Domestic | Ck/CT/90 | 5.0 ± 1.5 | 0 | 1.5 ± 2.6 | (3/3) | Intermediate | |
| Domestic | Ck/PA/91 | < | 0 | 5.0 ± 0.5 | (3/3) | Low | |
| Domestic | Ck/NY/91 | 10.0 ± 5.3 | 0 | 0.3 ± 0.6 | ND | Intermediate | |
| Domestic | GF/NY/94 | 4.0 ± 4.3 | 0 | 3.2 ± 2.7 | ND | Low | |
| Domestic | Dk/NJ/95 | 5.0 ± 1.9 | 0 | 2.8 ± 0.5 | (3/3) | Intermediate | |
| Domestic | GF/NY/95 | 5.0 ± 1.7 | 0 | 6.0 ± 0.7 | (3/3) | Intermediate | |
| Domestic | Ck/NY/95 | 14.0 ± 5.5 | 0 | 0.3 ± 0.6 | (3/3) | High | |
| Domestic | Ck/NJ/95 | 24.0 ± 5.4 | 60 | (2/2) | High | ||
| Domestic | Ck/NY/04 | < | 0 | 3.0 ± 3.3 | (3/3) | Low | |
| Domestic | Ck/PA/04 | 5.0 ± 3.1 | 0 | 6.0 ± 0.7 | (3/3) | Intermediate | |
| Nonavian | Swine | Sw/MO/06 | 25.0 ± 2.4 | 100 | 6.4 ± 0.3 | < | High |
| Mouse adapted | PR/8 | 26.0 ± 0.9 | 100 | 7.5 ± 0.0 | < | High | |
| Mock (PBS) | < | 0 | < | (0/3) | N/A |
“Category” indicates geographic region or a nonavian isolate.
Corresponds to the point during infection at which the group displayed the maximum decrease from starting weight (% starting weight ± SD); <, no statistical loss of weight at any time point.
Mean lung titer (Log10 EID50/ml ± SD) at 5 days postinfection.
Assessed by hemagglutination inhibition assay of horse red blood cells. Parentheses represent the number of animals that seroconverted to titers of ≥1:20 out of total surviving animals sampled. “<” represents a titer below the cutoff of 1:20 serum dilution or no surviving animals. ND, not determined.
High, >10% loss of starting weight; intermediate, 5% to 10% loss; low, <5% loss.
Isolate Mal/Pot177/83 is subtype H2N1.