TABLE 5.
Pathogenicity and transmission of avian H2N2 influenza viruses in ferrets
| Virus | Donor ferrets |
Direct-contact ferrets |
||||
|---|---|---|---|---|---|---|
| No. of ferrets shedding (n = 2)a | Clinical signs (no. of ferrets/total)b | No. of ferrets with seroconversion, (assay range)c | No. of ferrets shedding (n = 2)a | Clinical signs (no. of ferrets/total)b | No. of ferrets with seroconversion, (assay range)c | |
| Avian | ||||||
| Mal/MT/61 | 2 | Sneezing (1/2) | 2 (320) | 2 | None | 2 (320) |
| Dk/HK273/78 | 0 | None | 2 (20–40) | 0 | None | < |
| Dk/HK319/79 | 2 | None | 2 (80–160) | 2 | None | 1 (320) |
| Mal/Pot177/83e | 1 | None | 2 (160) | 0 | None | 2 (20) |
| Mal/Pot179/83 | 2 | None | 2 (160) | 1 | None | 2 (20–160) |
| Ck/Jena/84 | 2 | None | 2 (160) | 0 | None | < |
| Dk/NJ/95 | 0 | None | 2 (40–80) | 0 | None | <d |
| GF/NY/95 | 0 | None | 1d (80) | 0 | None | < |
| Ck/NJ/95 | 0 | None | 2 (20–40) | 0 | None | < |
| Nonavian and control | ||||||
| Sw/MO/06 | 2 | Weight loss (2/2), sneezing (2/2) | 2 | 2 | Sneezing (2/2) | 2 |
a
Number of animals with >1 Log10 TCID50/ml nasal titer out of total animals.
b
Numbers in parentheses are numbers of animals displaying signs out of the total.
c
Number of animals (n = 2) that seroconverted to homologous virus. Assessed by HI assay; titers are representative of the reciprocal of the highest doubling dilution that inhibited 4 hemagglutinating units of homologous virus with horse red blood cells. <, titers below assay cutoff of <1:20.
d
One animal in this group died due to adverse reaction to ketamine injection at 4 dpi.
e
Isolate Mal/Pot177/83 is subtype H2N1.