FIG 1.
Viral growth, host cell infection, and within-host diversification dynamics predicted by the stochastic model for the following parameter values: La = 3 aa, V0 = 1 × 103, a = 1.0 × 10−3 day−1, b = 3.0 day−1, r0 = 6.0 day−1, μ = 1.0 × 10−5, and U0 = 1 × 106. (A) Viral titer and uninfected cell number U0. Symbols represent the experimental data from references 20 and 38, plotted assuming a scaling factor of 1 viral count per 1 TCID50/ml. (B) Total numbers of genotypes (nucleotide and amino acid sequences) as a function of time.