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MLN4924 inhibits ancient SIV Vpr- and HIV-2 Vpx-mediated degradation of SAMHD1. (A and B) HEK293T cells were cotransfected with a SAMHD1-HA expression vector and Vpx or Vpr or their respective control vector. At 24 h after transfection, the cells were DMSO treated or treated with MG132/MLN4924 for 24 h. Expression levels of SAMHD1-HA and Vpx-HA were assessed by immunoblotting with an anti-HA antibody. β-Actin was used as the loading control.
