FIG 4.

STAT3 is necessary for outgrowth of proliferating B cells following EBV infection. Primary B cells from a healthy subject were infected with EBV in the absence (E) or presence (E+A) of AG490; primary B cells from two patients with AD-HIES [AD-HIES (1) and AD-HIES (2), with different mutations in the SH2 domain] were also infected with EBV. Cells were harvested at various times after EBV infection, and live cells were counted by Trypan blue staining. Representative growth curves are shown. Experiments were performed more than three times.