TABLE 1.
Activities of gL mutants
| Mutant | Activity relative to wild typea |
|
|---|---|---|
| gH/gL traffickingb | Cell-cell fusion | |
| Y26F | +++++ | +++++ |
| Y26A | +++++ | ++++ |
| Y26E | +++++ | +++ |
| V27A | +++++ | ++++ |
| V27D | +++++ | +++ |
| R29A | +++++ | +++++ |
| R31A | +++++ | +++++ |
| V32A | ++++ | ++++ |
| R34A | +++++ | +++++ |
| E35A | +++++ | +++++ |
| V36A | ++++ | ++++ |
| D38A | +++ | +++ |
| L40A | ++++ | ++++ |
| L40D | ++++ | ++++ |
| K41A | ++++ | ++++ |
| K41E | +++ | +++ |
a
Result (percentage) relative to wild type gL: +++++, 80 to 100%; ++++, 60 to 79%; +++, 40 to 59%; ++, 20 to 39%; +, 0 to 19%.
b
gH/gL cell surface expression.