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. 2014 Jan;88(1):176–187. doi: 10.1128/JVI.02098-13

FIG 3.

FIG 3

Qualitative features of HIV-specific CD8+ T cell responses restricted by HLA-B*57 (black circles) or nonrestricted by HLA-B*57 (gray circles in HLA-B*57+ subjects and clear circles in HLA-B*57− subjects). (A) Percentages of HIV-specific CD8+ T cells CFSELow after 6 days of culture with the appropriate peptide. (B and C) Percentages of cytokine-producing CD8+ T cells after 15 h of HIV-specific stimulation: IL-2 production (B) and IFN-γ production (C). (D to G) Differentiation phenotype of HIV-specific CD8+ T cells: CD127 expression (D), central memory phenotype (CCR7+ CD45RO+) (E), effector memory phenotype (CD27+ CD45RO+) (F), and expression of the senescence marker CD57 (G). (H and I) Expression of the activation markers CD38 (H) and HLA-DR (I) by HIV-specific CD8+ T cells.