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. 2014 Jan;88(1):763–767. doi: 10.1128/JVI.02687-13

FIG 2.

FIG 2

IFN-α/riba induction of cumulative restriction (CuRe) score to supraphysiologic levels correlates with viral load reduction. (A) Relationship between HIV-1 load reduction during IFN-α/riba therapy and CuRe score fold induction in PBMCs; no significant correlation was observed. (B) Relationship between HIV-1 load reduction during IFN-α/riba therapy and CuRe score fold induction in CD4+ T cells. Significance was assessed using Pearson's r correlation coefficient. (C) Comparison between CuRe scores of SHCS subjects undergoing IFN-α/riba therapy and of HIV-1-negative and HIV-1-infected (ART-naïve) viremic individuals enrolled in the SCOPE cohort. (D) Comparison of levels of expression of ISG15 (a marker of interferon exposure) between SHCS subjects undergoing IFN-α/riba therapy and HIV-1-negative and HIV-1-infected (ART-naïve) viremic individuals enrolled in the SCOPE cohort. Mann-Whitney tests were employed to determine significance.