FIG 1.

Shortest-paths diagram for kinase control of latent HIV-1 infection. Source Uniprot identification numbers (IDs) for phosphopeptides that were found increased in three analyzed latently HIV-1 infected T cell lines (CA5, EF7, and J89GFP) over parental Jurkat T cells along with the Uniprot ID for PIM-1 were uploaded to GeneGo MetaCore (Thomson Reuters) as seed nodes for network analysis using Dijkstra's shortest-paths algorithm to identify directed interactions among these seed nodes. PIM-1's interactions were selected (highlighted paths), with PIM-1 canonical pathway interactions highlighted in light blue, and other PIM1 interactions highlighted in yellow. NF-κB was the most interconnected node, and its interaction with PIM-1 is highlighted in dark blue.