TABLE 3.

Comparison of amino acid identities of seven conserved replicase domains of the hedgehog coronavirus and prototype clade c betacoronaviruses for species delineation

Domain	% amino acid sequence identity (range):
	Within EriCoVa	Of EriCoV compared to:
		MERS-CoVb	HKU4c	HKU5d
ADRP	96.9–100	71.3	57.5–59.4	61.3–61.9
NSP5 (3CLpro)	99.0–100	79.1–79.7	72.9–73.5	76.8–77.1
NSP12 (RdRp)	99.0–100	88.9–89.4	87.2–88.1	88.1–88.7
NSP13 (Hel, NTPase)	99.6–100	91.1–91.5	89.5–90.0	90.3–90.8
NSP14 (ExoN, NMT)	99.6–100	89.5–89.9	83.2–84.3	88.0–88.4
NSP15 (NendoU)	97.1–100	82.5–83.1	74.3–75.4	78.4–79.3
NSP16 (OMT)	99.0–100	86.5–87.5	81.5–82.1	83.8–85.1
Concatenated domains	98.9–100	86.9	82.4–82.8	84.8–85

^aIncluding sequences with accession numbers KC545383 and KC545386.

^bIncluding sequences with accession numbers JX869059 and KC164505.

^cIncluding sequences with accession numbers EF065505, EF065506, EF065507, EF065508, and DQ648794.

^dIncluding sequences with accession numbers EF065509, EF065510, EF065511, and EF065512.