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SIVmac Vpx could inactivate diverse primate but not nonprimate SAMHD1 proteins with divergent C-terminal sequences. (A) Alignment of the C-terminal regions of the indicated mammalian SAMHD1 protein sequences. (B) Degradation of coexpressed Rh, Hu, and Pongo SAMHD1 proteins was observed in SIVmac Vpx-transfected HEK293T cells. The Canis, Mus, and Bos SAMHD1 proteins were, however, resistant to SIVmac Vpx-induced degradation.
