FIG 3.

Chimeric VLPs elicited neutralizing antibody responses in mice. Groups of six mice were immunized i.p. at weeks 0, 2, and 4 with PBS, HBc, HBcSP55, or HBcSP70 as described in Materials and Methods. At week 6, sera were collected from each mouse. The antisera were diluted 1:100 with PBS and used in an ELISA to determine the HBc-specific antibody response (A), the SP55-specific antibody response (B), and the SP70-specific antibody response (C). (D) Antisera were serially diluted, starting from 1:8, to determine neutralizing titers against EV71/G082. Each symbol represents an individual mouse, and the line indicates the geometric mean value of the group.