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. Author manuscript; available in PMC: 2014 Feb 3.
Published in final edited form as: Dev Biol. 2010 Jun 9;344(2):836–848. doi: 10.1016/j.ydbio.2010.05.514

Figure 1.

Figure 1

Notch pathway gene expression in trigeminal placode development. Notch1 mRNA is expressed at low levels in ectodermal cells of the midbrain region at HH stage 10-11 (b). Notch1 mRNA expression appears more intense in ectodermal cells (e) at HH stage 12-13 (c) and the expression is faint by HH stage 17 (d). At HH stage 10-11, Delta1 mRNA is expressed at low levels in ectodermal cells of the midbrain region (g). Delta1 mRNA expression levels appear more intense in ectodermal cells (j) at HH stage 12-13 (h) but expression appears slightly fainter by HH stage 17 (i). Serrate1 mRNA is not expressed in the ectodermal cells (k-o) of the trigeminal placode. Lunatic fringe mRNA is expressed at low levels in ectodermal cells of the midbrain region at HH stage 10-11 (q). At HH stage 12-13, Lunatic fringe expression appears more robust in ectodermal cells (r, t) but is faint by HH stage 17 (s). Hes1 mRNA expression was detected at low levels in the midbrain ectoderm at HH stage 10-11 (v). Hes1 expression appears intense in the midbrain ectoderm (y) at HH stage 12-13 (w) and faint expression was detected at HH stage 17 (x). Ngn2 mRNA expression was detected at moderate levels in the trigeminal placode at HH stage 10-11 (aa). Ngn2 mRNA expression levels are most easily detected at HH stage 12-13 (bb, dd) and are more faint by stage 17 (cc). Notch signaling was not detected in the midbrain ectoderm at HH stage 9 (a, f, k, p, u).