FIG 5.

Therapeutic efficacy of S. aureus CP8-TT conjugate vaccines administered alone or in combination with ClfA or dHla. Groups of 8 or 9 rats were immunized according to a therapeutic scheme (vaccination after bacterial challenge) and challenged by the intratibial route with S. aureus HU-92a. Effects of immunization on bacterial load (CFU/bone) (A) and OI (mm) (B). Each dot represents determinations made on individual rats, and the bars represent the geometric means (bacterial load) or the arithmetic means (OI) of each group. Comparisons were performed by one-way ANOVA followed by the Bonferroni posttest, and the P values for relevant comparisons are shown. (C) Correlation of the bacterial load (CFU/bone) and the OI (mm) (Spearman's rank correlation test).