FIG 3.

Comparable B. hermsii-specific antibody responses in wild-type and TACI^−/− mice. (A, C, and D) Wild-type (n = 9) or TACI^−/− (n = 11) mice were infected intravenously with 5 × 10⁴ B. hermsii bacteria (strain DAH-p1); bacteremia was monitored by dark-field microscopy as described previously (3) (C), and B. hermsii-specific IgM (A) and FhbA-specific IgM (D) were measured by ELISA. These data represent the pooled data from two independent experiments. (B) B. hermsii-specific IgG from B. hermsii-infected wild-type (n = 3) or TACI^−/− (n = 3) mice was measured by ELISA. The data shown are representative of two independent experiments. Means ± standard deviations are shown for all panels. Differences in the antibody responses and bacteremia were not statistically significant when analyzed by two-way ANOVA with significance reached at a P value of <0.05.