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CTC graded toxicities—numbers of patients
| Toxicity | Grade | Placebo | 750mg | 1,000mg | 2,000mg | P value |
|---|---|---|---|---|---|---|
| Agitation | Grade 1 (N) | 7 | 6 | 6 | 6 | 0.38 |
| Grade 2 (N) | 0 | 1 | 0 | 0 | ||
| Grade 3 (N) | 0 | 0 | 0 | 1 | ||
| Anxiety | Grade 1 (N) | 7 | 6 | 6 | 10 | 0.38 |
| Grade 2 (N) | 2 | 5 | 3 | 1 | ||
| Grade 3 (N) | 0 | 0 | 0 | 1 | ||
| Insomnia | Grade1 (N) | 28 | 22 | 19 | 19 | 0.57 |
| Grade 2 (N) | 2 | 5 | 5 | 3 | ||
| Grade 3 (N) | 2 | 4 | 1 | 1 | ||
| Nausea | Grade1 (N) | 13 | 14 | 17 | 16 | 0.64 |
| Grade 2 (N) | 2 | 8 | 8 | 5 | ||
| Grade 3 (N) | 1 | 2 | 1 | 1 | ||
| Vomiting | Grade1 (N) | 3 | 5 | 7 | 5 | 0.29 |
| Grade 2 (N) | 0 | 5 | 5 | 4 | ||
| Grade 3 (N) | 2 | 2 | 1 | 1 |
