Table 1.
NTG | CREB-S133A-LZ | CREB-S133A | |
---|---|---|---|
n | 7 | 6 | 5 |
Heart rate, beats/min | 538±25 | 612±23 | 611±28 |
Diastolic pressure, mmHg | 95.5±6.4 | 89.4±4.2 | 66.6±3.0*,† |
Diastolic pressure, mmHg | 65.4±6.3 | 61.9±5.8 | 54.3±3.6 |
dP/dtmax, mmHg/s | 11,676±532 | 7,527 ±501* | 6,480±189* |
dP/dtmin, mmHg/s | 12,151±550 | 8,316±625* | 5,588±435*,† |
Values are means ± SE; n, number of animals. MHC, myosin heavy chain; TG, transgenic; NTG, nontransgenic; dP/dtmax and dP/dtmin, maximum and minimum first derivative of left ventricular (LV) pressure during contraction and relaxation, respectively.
P < 0.05 vs. NTG mice; and
P < 0.05 vs. cAMP response element binding protein (CREB)-S133A-leucine zipper (LZ) mice.