Table 2. Univariate and multivariate analyses of nestin expression in relation to overall survival.

Variable	Univariateanalysis		Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Nestin-high	3.421	1.360–8.607	0.009	3.366	1.099–10.314	0.034
Nestin-low	1.000			1.000
Adeno	1.119	0.524–2.390	0.772	2.150	0.860–5.372	0.101
SCC	1.000			1.000
Poor	4.472	1.661–12.036	0.003	2.402	0.784–7.355	0.125
Well andmoderate	1.000			1.000
TNM III+IV	3.276	1.907–5.627	0.001	2.358	1.329–4.186	0.003
TNM I+II	1.000			1.000
Male	0.819	0.339–1.976	0.657	0.530	0.201–1.396	0.199
Female	1.000			1.000
Age >60 y	0.988	0.953–1.024	0.505	1.021	0.976–1.068	0.359
Age ≤60 y	1.000			1.000
Smoking	0.837	0.358–1.958	0.681	0.653	0.245–1.743	0.395
Non-smoking	1.000			1.000

Abbreviations: HR, hazard ratio estimated from Cox proportional hazards regression model; CI, confidence interval of estimated HR; Adeno, adenocarcinoma; SCC, squamous cell carcinoma.