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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Oncogene. 2012 Nov 5;32(40):4814–4824. doi: 10.1038/onc.2012.494

Figure 4. Increased mitochondrial fusion inhibits migration and invasion of breast cancer cells.

Figure 4

MDA-MB-231 and MDA-MB-436 cells, transfected with GFP, GFP-tagged Mfn1 or Mfn2 for 24h, were collected for Western blot analysis of Mfn1 and Mfn2 (a), or subjected to migration and invasion assays (b) n=3, mean ± s.e.m., *p<0.05. (c) Representative confocal images of MDA-MB-231 and MDA-MB-436 cells, expressing GFP or GFP-tagged Mfn1, stained with MitoTracker Red, show mitochondrial morphology. Mitochondria are in red, GFP is in green, and the nucleus is in dark blue. Scale bar, 10 μm.