Figure 4. Dependency of the polyphenol's ameliorative effect on the CAR gene.

A, Oil red O staining of the liver sections from CAR KO mice fed under the same conditions as described in Fig. 1. Larger numbers of oil drops were observed in the sections of mice fed the ethanol, the ethanol plus ellagic acid, or the ethanol plus trans-resveratrol diet compared with that of the control diet. B, Quantification of oil drop intensities per section. Differences (n = 3, Tukey-Kramer multiple comparison) were observed between the control group (a) and the other groups (b). Scale bar, 10 µm.