Table 5. Summary of the predicted polyphenol's effect on metabolism.
Metabolic pathways | EtOH vs control | EtOH+EA or RSV vs EtOH | EtOH+EA or RSV vs control |
TCA cycle | down | up | up |
Steoid and Bile acid synthesis * | down | up | up |
β-oxidation * | down | up | up |
α-oxidation | down | up | up |
Tetrahydrofolate metabolism | down | up | up |
Core clock (day) | up | down | down |
Glycogen synthesis * | down | up | |
Long chain unsaturated fatty acid synthesis | down | up | |
Glycolysis | up | down | |
Pentose phosphate pathway | up | down | |
Gluconegenesis | up | ||
NAD synthesis | up | ||
Methionine metabolism | up | ||
Urea cycle | up | ||
Core clock (night) | up | ||
Clock output regulators | up |
: metabolic pathways that include CAR-regulated gene products.