Figure 4. Dimerization of TbPRMT6.

(A) Two views of the TbPRMT6 dimer Monomer A is shown as a cartoon colored in magenta, and monomer B is colored in gray and shown through a surface presentation (B) Dimerization interactions The left image represents the hydrogen bond interactions on the dimeric interface, and the right image represents the hydrophobic interactions (C) SAXS results of TbPRMT6_L The experimental SAXS curve of TbPRMT6 and the data points up to q  = 06 Å⁻¹ are plotted The top-right inset is the PDDF calculated by GNOM, and the bottom-left inset is the DR model with the crystal structure superimposed with a TbPRMT6 dimer The R_g and D_max of TbPRMT6 are 328±01 Å and 959 Å, respectively The DR models were generated by GASBOR using the final χ against the raw SAXS data of 063 The X-ray structure of the TbPRMT6 dimer can be superimposed onto the DR models quite well, with an NSD of 109.