Table 2. Association of the rs780094 C→T GCKR SNP with anthropometric, biochemical, metabolic and histological features in 366 Patients with Non-alcoholic Fatty Liver Disease.
| Variable | GCKR CC N = 60 | GCKR CT n = 179 | GCKR TT n = 127 | Univariate Analysis p value° |
| Mean age – years | 42.2±13.0 | 43.3±12.6 | 44.9±11.8 | 0.33 |
| Males | 48 | 127 | 86 | 0.22 |
| Mean body mass index – kg/m2 | 28.5±4.6 | 28.7±4.4 | 29.1±4.5 | 0.61 |
| Alanine aminotransferase – IU/L | 81.6±70.6 | 81.4±52.1 | 73.4±48.0 | 0.40 |
| Cholesterol – mg/dL | 198.6±47.9 | 202.4±40.9 | 209.5±48.5 | 0.23 |
| HDL cholesterol – mg/dL | 50.2±18.2 | 48.9±13.2 | 47.1±12.2 | 0.32 |
| Triglycerides – mg/dL | 139.8±83.3 | 138.0±69.8 | 158.3±96.3* | 0.09 |
| Blood glucose – mg/dL | 91.4±18.6 | 96.6±27.7 | 95.8±18.5 | 0.32 |
| Insulin – µU/mL | 15.1±9.8 | 16.0±9.1 | 15.4±11.5 | 0.78 |
| HOMA-score | 3.65±3.23 | 3.96±3.03 | 3.70±3.05 | 0.68 |
| HOMAbeta % | 144.4±63.7 | 144.6±71.5 | 131.8±61.0 | 0.25 |
| Diabetes | 8 | 21 | 18 | 0.81 |
| Arterial hypertension | 14 | 41 | 38 | 0.35 |
| Steatosis grade 3 | 13 | 44 | 37 | 0.49 |
| Lobular Inflammation Grade 2–3 | 17 | 53 | 34 | 0.86 |
| Ballooning | 46 | 151 | 105 | 0.39 |
| NAS ≥5 | 24 | 82 | 51 | 0.54 |
| Fibrosis >F1 | 17 | 71 | 70 | 0.001 |
Data are given as mean ± SD or as number of cases. HDL: high-density lipoprotein; HOMA: homeostasis model assessment.
°
by ANOVA;
*
p = 0.02 versus GCKR CC/CT.