Table 2. Association of the rs780094 C→T GCKR SNP with anthropometric, biochemical, metabolic and histological features in 366 Patients with Non-alcoholic Fatty Liver Disease.

Variable	GCKR CC N = 60	GCKR CT n = 179	GCKR TT n = 127	Univariate Analysis p value°
Mean age – years	42.2±13.0	43.3±12.6	44.9±11.8	0.33
Males	48	127	86	0.22
Mean body mass index – kg/m2	28.5±4.6	28.7±4.4	29.1±4.5	0.61
Alanine aminotransferase – IU/L	81.6±70.6	81.4±52.1	73.4±48.0	0.40
Cholesterol – mg/dL	198.6±47.9	202.4±40.9	209.5±48.5	0.23
HDL cholesterol – mg/dL	50.2±18.2	48.9±13.2	47.1±12.2	0.32
Triglycerides – mg/dL	139.8±83.3	138.0±69.8	158.3±96.3*	0.09
Blood glucose – mg/dL	91.4±18.6	96.6±27.7	95.8±18.5	0.32
Insulin – µU/mL	15.1±9.8	16.0±9.1	15.4±11.5	0.78
HOMA-score	3.65±3.23	3.96±3.03	3.70±3.05	0.68
HOMAbeta %	144.4±63.7	144.6±71.5	131.8±61.0	0.25
Diabetes	8	21	18	0.81
Arterial hypertension	14	41	38	0.35
Steatosis grade 3	13	44	37	0.49
Lobular Inflammation Grade 2–3	17	53	34	0.86
Ballooning	46	151	105	0.39
NAS ≥5	24	82	51	0.54
Fibrosis >F1	17	71	70	0.001

Data are given as mean ± SD or as number of cases. HDL: high-density lipoprotein; HOMA: homeostasis model assessment.

^°by ANOVA;

^*p = 0.02 versus GCKR CC/CT.