Table 3. Distribution of clinical signs associated with visceral leishmaniasis in dogs with evidence of infection by L. infantum and type 1 (normal) or type 3 (moderately to severely disorganized) splenic white pulp.
| PARAMETER | SPLEEN TYPE 1 | SPLEEN TYPE 2 | SPLEEN TYPE 3 | TOTAL (%) | ||||
| N | 54 | (100) | 99 | (100) | 46 | (100) | 199 | (100) |
| Spleen type: | ||||||||
| Type 1 | 54 | (100) | 54 | (27) | ||||
| Type 2 | 99 | (100) | 99 | (50) | ||||
| Type 3 | 46 | (100) | 46 | (23) | ||||
| Clinical classification: | ||||||||
| Asymptomatic | 10/54 | (18) | 11/99 | (11) | 1/46 | (2) | 22/199 | (11) |
| Symptomatic | 44/54 | (82) | 88/99 | (89) | 45/46 | (98)b | 177/199 | (89) |
| Clinical signs: | ||||||||
| Alopecia | 14/54 | (26) | 44/99 | (44) | 25/46 | (54)c | 83/199 | (42) |
| Anemia | 10/33 | (30) | 31/70 | (44) | 22/36 | (61)a | 63/139 | (45) |
| Conjunctivitis | 9/28 | (32) | 15/47 | (32) | 17/30 | (57) | 41/105 | (39) |
| Dehydration | 5/28 | (18) | 19/56 | (34) | 11/23 | (48)a | 35/107 | (33) |
| Dermatitis | 6/26 | (23) | 24/43 | (56) | 13/23 | (56)a | 43/92 | (47) |
| Emaciation | 19/54 | (35) | 43/99 | (43) | 24/46 | (52) | 86/199 | (43) |
| Erosion | 8/28 | (29) | 18/56 | (32) | 9/23 | (39) | 35/107 | (33) |
| Lymphadenopathy | 23/52 | (44) | 58/99 | (59) | 34/46 | (74)c | 115/197 | (58) |
| Onychogryphosis | 7/54 | (13) | 29/97 | (30) | 16/45 | (36)b | 52/196 | (27) |
| Pustule | 3/28 | (11) | 12/56 | (21) | 2/23 | (9) | 17/107 | (16) |
| Splenomegaly | 20/33 | (61) | 40/66 | (61) | 15/26 | (58) | 75/125 | (60) |
| Ulceration | 4/28 | (14) | 8/56 | (14) | 7/23 | (30) | 19/107 | (18) |
Chi-square test for trends:
a
P<0.05,
b
P<0.01,
c
P<0.005. The denominator varies according to the availability of the recorded data for each clinical sign.