Table 5. Distribution of laboratory results in dogs with quiescent (negative spleen culture) or active (positive spleen culture) infection by L. infantum and type 1 (normal) or type 3 (moderately to severely disorganized) splenic white pulp (WP).

CLINICAL	WITH NEGATIVE SPLEEN CULTURE				WITH POSITIVE SPLEEN CULTURE
PARAMETER	SPLEEN TYPE 1		SPLEEN TYPE 3		SPLEEN TYPE 1		SPLEEN TYPE 3
	MEDIAN	[p25–p75; N]	MEDIAN	[p25–p75; N]	MEDIAN	[p25–p75; N]	MEDIAN	[p25–p75; N]
Albumin	2.8	[2.4–3.4; 21]c	2.6	[2.5–3.2; 16]b	2.7	[2.2–4.0; 9]b’	1.8	[1.4–2.3; 8]b,b’, c
Globulin	4.8	[3.9–7.2; 21]	7.0	[5.2–9.7; 16]	4.6	[4.0–6.6; 9]	5.7	[4.0–6.5; 8]
ALT	23	[20]–[32]; [9] a	36	[29–46; 11]	26	[25]–[27]; [2]	57	[38–95; 5]a
AST	34	[30–41; 9]	37	[25–50; 11]	32	[27]–[37]; [2]	40	[34–63; 5]
Urea	30	[22–42; 21]	30	[25–44; 16]	46	[30–54; 9]	41	[22–45; 8]
Creatinine	0.9	[0.7–1.2; 21]a	0.8	[0.7–0.9; 16]	1.0	[0.8–1.1; 9]b	0.7	[0.4–0.8; 8]a,b
Cholesterol	162	[142–183; 9]	180	[161–203; 11]	180	[142–218; 2]	238	[136–358; 5]
Triglycerides	42	[31–74; 9]	55	[43–98; 11]	76	[68–85; 2]	41	[40–72; 5]
C-reactive protein	28	[9–54; 9]	ND		32	[17–40; 10]	44	[39–48; 10]
Hematocrit	38	[27–43; 9]a	31	[29]–[38]; [11]	42		19	[17]–[27]; [5] a
Hemoglobin	13	[9]–[14;9] a	11	[10]–[12;11]	14		7	[6]–[9]; [5] a
WBC count	14	[13]–[15]; [9]	14	[8]–[19;11]	18		28	[15–46; 5]
Neutrophils	60	[42–74; 9]a	68	[49–78; 11]	36		82	[80–83; 4]a
Monocytes	5	[3]–[7]; [14]	2	[2]–[3]; [4]	8	[8]–[9]; [2]	4	[1]–[6;6;4]
Lymphocytes	16	[12]–[24;14]	43	[14–77; 4]	22	[12]–[31]; [2]	8	[4]–[18;6]
Eosinophils	4	[1]–[8]; [14]	1	[0–4; 4]	12	[10]–[14]; [2]	2	[1]–[9;6]
Platelets	130	[57–168; 9]	161	[96–232; 11]	161		155	[80–375; 5]

p25–p75 = interquartile range; ALT = alanine aminotransferase; AST = aspartate aminotransferase;

^aP<0.05,

^{b, b’}P<0.01,

^cP<0.001 (Kruskal-Wallis test): animal groups with significant differences in the laboratory test are identified by the same character (^a, ^b, ^b’, or ^c).