Table 3. HLA-DRB1 genotype frequency in the SLE patients and controls relative to SLE phenotype.
| n | *15:01/alleles other than *13:02, or *14:03 | P | OR | Q | 95%CI | *15:01/*13:02, or *14:03 | P | OR | Q | 95%CI | |
| age of onset < 20 | 144 | 36 (25.0) | 7.58×10−5 | 2.47 | 0.0001 | (1.60–3.80) | 1 (0.7) | 0.4920 | 0.39 | 0.8806 | |
| anti-Ro/SS-A antibodies (+) | 326 | 80 (24.5) | 2.13×10−7 | 2.41 | 6.04×10−7 | (1.74–3.34) | 4 (1.2) | 0.6138 | 0.69 | 0.8806 | |
| anti-La/SS-B antibodies (+) | 70 | 14 (20.0) | 0.0591 | 1.85 | 0.0628 | 1 (1.4) | 1.0000 | 0.81 | 1.0000 | ||
| anti-RNP antibodies (+) | 240 | 60 (25.0) | 1.62×10−6 | 2.47 | 3.07×10−6 | (1.72–3.53) | 1 (0.4) | 0.2192 | 0.23 | 0.8806 | |
| anti-Sm antibodies (+) | 220 | 51 (23.2) | 5.14×10−5 | 2.23 | 7.49×10−5 | (1.53–3.25) | 2 (0.9) | 0.5478 | 0.51 | 0.8806 | |
| anti-dsDNA antibodies (+) | 603 | 148 (24.5) | 5.53×10−10 | 2.41 | 3.13×10−9 | (1.82–3.18) | 7 (1.2) | 0.3916 | 0.65 | 0.8806 | |
| antiphospholipid syndrome (+) | 165 | 37 (22.4) | 0.0007 | 2.14 | 0.0009 | (1.41–3.26) | 1 (0.6) | 0.4925 | 0.34 | 0.8806 | |
| malar rash (+) | 301 | 90 (25.4) | 2.08×10−8 | 2.52 | 8.85×10−8 | (1.83–3.45) | 2 (0.7) | 0.2655 | 0.37 | 0.8806 | |
| discoid rash (+) | 116 | 84 (27.9) | 5.28×10−10 | 2.87 | 3.13×10−9 | (2.07–3.97) | 2 (1.7) | 1.0000 | 0.98 | 1.0000 | |
| photosensitivity (+) | 238 | 28 (24.1) | 0.0007 | 2.36 | 0.0009 | (1.47–3.78) | 3 (1.3) | 0.7770 | 0.71 | 0.8806 | |
| arthritis (+) | 410 | 60 (25.2) | 1.44×10−6 | 2.50 | 3.06×10−6 | (1.74–3.57) | 4 (1.0) | 0.3336 | 0.55 | 0.8806 | |
| serositis (+) | 161 | 96 (23.4) | 3.46×10−7 | 2.26 | 8.41×10−7 | (1.66–3.08) | 0 (0.0) | 0.1477 | 0.17 | 0.8806 | |
| renal disorder (+) | 380 | 35 (21.7) | 0.0015 | 2.06 | 0.0017 | (1.34–3.16) | 5 (1.3) | 0.6354 | 0.74 | 0.8806 | |
| neurologic disorder (+) | 130 | 93 (24.5) | 7.01×10−8 | 2.40 | 2.38×10−7 | (1.76–3.28) | 3 (2.3) | 0.7219 | 1.31 | 0.8806 | |
| hemolytic anemia (+) | 95 | 35 (26.9) | 1.84×10−5 | 2.73 | 3.14×10−5 | (1.76–4.24) | 2 (2.1) | 0.6857 | 1.20 | 0.8806 | |
| lymphopenia (+) | 459 | 18 (18.9) | 0.0708 | 1.73 | 0.0708 | 4 (0.9) | 0.2335 | 0.49 | 0.8806 | ||
| thrombocytopenia (+) | 180 | 122 (26.6) | 5.58×10−11 | 2.68 | 9.49×10−10 | (2.00–3.60) | 2 (1.1) | 0.7513 | 0.62 | 0.8806 | |
| Control | 849 | 101 (11.9) | 15 (1.8) |
SLE: systemic lupus erythematosus, OR: odds ratio, CI: confidence interval. Genotype frequencies are shown in parenthesis (%). Associations were tested by Fisher's exact test using 2×2 contingency tables. To correct for multiple testing, the false discovery rate Q-value was calculated.