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. 2014 Feb 3;9(2):e87705. doi: 10.1371/journal.pone.0087705

Figure 4. Immunohistochemistry (IHC) of CD8+ tumor infiltrating lymphocytes (TIL).

Figure 4

There was a significant increase in CD8+ T cells from baseline to week 6 (Wilcoxon signed-rank test p = 0.02; N = 24 patients). (A) Boxplots of IHC scores of CD8+ TIL at baseline and week 6. Total counts from the same patient at the two time points are connected by light gray lines. (B) Plot of the median change in CD8+ TIL at week 6 (compared to baseline) with corresponding 95% confidence intervals. (C–D) Example of baseline and week 6 tumor CD8+ TIL (stained brown) by IHC. Magnification: 20×.