Figure 2. Viability of RENCA macrobeads following paclitaxel or docetaxel treatment. A quantitative assessment of the percent of colonies that remained viable and the average number of viable nuclei per colony in treated macrobeads. Typical levels of colony viability and the number of viable nuclei per colony were maintained in vehicle-treated macrobeads throughout the course of the study (A). When possible, an average of 3 replicate experiments was considered. Statistically significant outcome differences for paclitaxel-treated macrobeads (B) or docetaxel-treated macrobeads (C), as compared with vehicle-treatment, are denoted with an asterisk (*), P < 0.05.