Table 1. Proteins directly regulated by AcnA.

Locus	function	loop sequence of IRE	localization	distance in bp*	fold change	p-value
WT
SSQG_00725	Tellurium resistance protein	CAGUG	5′	64	1.62	0.05
SSQG_01870	Phosphoglycerate kinase	CAGCG	5′	97	1.65	0.05
SSQG_01871	Glyceraldehyde-3-phosphate dehydrogenase	CAGCG	3′	35	1.46	0.02
SSQG_02023	Cell division protein FtsZ	GAGAG	5′	9	1.61	0.03
SSQG_02339	Tellurium resistance protein	GGGAG	3′	100	1.99	0.15
SSQG_03372	Glutathione peroxidase	CAGGG	5′	169	1.99	0.00
SSQG_03670	Phosphate-binding protein PstS	CAGGG	5′	155	0.49	0.07
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	0.61	0.01
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	0.56	0.04
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	1.60	0.07
SSQG_04792	Adenylate kinase	CUGUG	3′	79	2.23	0.02
SSQG_05742	1-deoxy-D-xylulose 5-phosphate reductoisomerase	CAGGG	5′	181	3.05	0.06
SSQG_05905	Conserved hypotetical protein	GAGAG	5′	182	1.54	0.01
MacnA
SSQG_00322	Stress inducible protein	CAGCG	3′	119	0.72	0.03
SSQG_01539	Glycerol operon regulatory protein	GAGAG	5′	90	1.59	0.11
SSQG_02132	Serine protease	CAGGG	3′	33	0.67	0.10
SSQG_02132	Serine protease	CAGGG	3′	44	0.67	0.10
SSQG_02339	Tellurium resistance protein	GGGAG	3′	100	0.41	0.00
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	1.38	0.06
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	1.29	0.04
SSQG_04757	Translation elongation factor Tu	GAGAG	5′	84	1.55	0.34

^*Distance of the IRE-like motifs in base pairs from start or stop codon.